An Outcome Becomes Predictable

• Emdogain initiates a natural process that mimics that of tooth development.
• Bone formation starts along the root surface and, in time, the defect fills with new alveolar bone.
• Epithelial cells are inhibited, preventing epithelia down growth into the defect.

Clinical documentation for Emdogain has been obtained from a series of strictly designed studies in the U.S. and Europe. Followed for over three years, patients have shown predictable improvement in Emdogain treated defects compared to control surgery by achieving statistical significance for probing pocket reduction, clinical attachment gain, and radiographic bone gain.

Clinical studies show that patients with deep periodontal pockets (more than 6 mm) of the 1-wall and 2-wall type may expect to achieve an average of 60-70% defect fill in intrabony defects. ^7,28,39

Bone gain/loss 3 years post treatment 7 As illustrated in the graph below, Emdogain has been shown to promote a steady maturation of bone over time.

Outcome at 12 months post-surgery (mean in mm): 28 PPD reduction 5.2 mm PAL gain 4.7 mm Radiographic bone gain 2.9 mm 99 of 145 sites gained > 4 mm PAL Only 8 of 145 sites gained < 2 mm PAL

Pre-treatment and one year post-treatment radiographs of a lower molar infrabony and furcation defect treated by Dr Gould